Monday, April 2, 2012

Outsmarting HIV with X-Ray Crystallography


Dr, Alian Akram, Lorry I. Lokey Center for Life Science & Engineering, Technion.

Outsmarting HIV



It sound like modern warfare, and indeed, even when aiming to outsmart a killer virus on a scale of about 100 nanometers, the latest technology makes all the difference. One of the deep passions behind Dr. Alian Akram’s pioneering crystallographic work in the Technion is a desire to advance treatments for HIV, the causative agent of AIDS.



Scientists in Akram’s lab investigate the general principles of how aggressive virus lock into the genetic resources of a patient - and how to prevent them from doing this. “It is a MUST to learn about the critical interactions and the mechanisms of resistance,” says Akram. The team is taking a sharp look at pathogen-host interaction and how the HIV virus literally hijacks the machinery of the host cell in order to replicate itself, and how it escapes the immune system. “We are hoping to determine the structures of key interacting molecules and develop new intervening strategies and drugs that prevent their interaction. We also want to understand the mechanism of emergent resistance in the proteins of this virus.”



Current drugs for HIV bind viral proteins - and yet it continues to mutate and regenerate. Akram’s team is working on a protein discovered in 2004 - intrinsic immunity APOBEC3G. This protein attacks the genome of HIV and causes hypermutation that leads to an abortive replication cycle for HIV. However, HIV expresses a protein that destroys APOBEC, so the Akram's group wants to understand this process better so that it can be blocked.
"Crystal structure of Pseudouridine synthase in complex with RNA solved by  Akram Alian. The structure reveals base-pair rearrangement as the key mechanism to rRNA substrate selectivity  (http://rnajournal.cshlp.org/content/16/6.cover-expansion)"

5 comments:

  1. Hi Alian;
    Good luck in your research. A few years ago I saw a TV show on survivors of the plaques that moved through europe. Through church records they Dillon found that there where survivors. Some of theses survivors' families still live today. Amongst them are Gay males who are immune to HIV. Your technology could possibly unlock that mystery in reverse.
    Sincerely
    James

    ReplyDelete
    Replies
    1. I found a great site. All articles are written by very intelligent people. And I want to share this with you. You must be mentioned here that has something for everyone.www.hobsonavocats.com |

      www.zeusportclub.com |

      www.worldatendoftricks.com |

      www.edgecliffautomotive.com |

      www.marcellusshalebusinessplan.com |

      www.snteducationaltrust.com |

      www.educationtransaction.com |

      Delete
  2. It is a have to to study about the critical connections and the mechanism of battle

    ReplyDelete
  3. Finally I found a great site. All articles are written by very intelligent people. And I want to share this with you. You must be mentioned here that has something for everyone.www.maryland-funeral-home.com |

    www.lbfdogs.com |

    www.sport-only.com |

    www.tutorial4designer.com |

    www.pacetransportationinc.com |

    www.nsncollegegames.com |

    www.shoppingdown.com |

    www.connecticuthomeenergysolutions.com |

    www.practicalenergylaw.com |

    www.additionsports.com |

    ReplyDelete
  4. In addition to the beauty of the girls and the need for such kind of decorative Gucci replica handbags bags, but also a very practical need large capacity bag. Perhaps the daily bag and not much use, but when you need to install two or three days of travel necessities, it is very convenient. Therefore, every girl is very necessary to prepare a bag for a rainy day in his closet! Gucci 2014 bag only has a large space, but very bright yellow and red copper spring atmosphere, coupled with a classic black and wild. In addition, Gucci 2014 bag comes with a shoulder strap, shoulder strap pad specifically added a very user-friendly design details! 2014 new Gucci bag was listed in major stores, the reference price of 1,600 dollars.Gucci replica sunny April day in the spring to bring you the latest fashion items: from the latest appearance of Gucci Swing Swing package, comfortable fit for Gucci Loafers, to Ms. favorite Gucci pumps heels. These colorful and beautiful works like a warm spring breeze blowing, so that April day more colorful and moving.This series package shall be made ​​by the Dollar leather, this fabric features a textured leather bag section on the hot embossing by stamping technology, and after a little leather dyeing effect matte; Because of this characteristic, produced the package shall naturally elegant, leather itself is relatively more wear-resistant. His possession "Made in Italy by Gucci" golden stamping highlight replica Gucci handbags handbags, Gucci also has been stuck to the "creation of Italy" in essence. Gucci Swing Swing package has a fashionable color: from basic black, deep cobalt blue, gray-brown to bright pink, soft pink, rust orange, yellow and sea blue Hornet, to meet you wear with different needs. In particular, this section lined with natural linen bag with large zippered pocket with cell phone pocket and blackberry pocket, hidden magnetic buckle top, at the time a more attractive design ensures both practical and safe, in addition, the thickness of the handle material design makes the hand grip is more comfortable for daily use.

    ReplyDelete